No audible wheezing
نویسندگان
چکیده
Mouse models of T helper type 2 (Th2) cell-biased pulmonary inflammation have elucidated mechanisms of sensitization, cell traffic, and induced airway hyperresponsiveness (AHR). Nonetheless, most mice lack intrinsic AHR, a central property of human asthma, and disparities persist regarding the contributions of eosinophils and mast cells and the sensitivity to induced AHR in the commonly used mouse strains. We suggest that these discordances, reflecting methodological and genetic differences, may be informative for understanding heterogeneity of human asthma.
منابع مشابه
A young man with dyspnoea and audible expiration: the loops never lie
Spirometry provides clues to solving this puzzle of dyspnoea and wheeze in a young nonsmoker-the loops never lie! http://ow.ly/YC9zI A 10 s recording of expiratory sounds from this case can be found at: http://ow.ly/UVVu300moD1.
متن کاملPertinent issues in diagnosis and management of wheezing in under-five children at community level.
Wheezing in acute respiratory infections is a rule rather than exception. A large proportion of children (up to 75%) having pneumonia or severe pneumonia as per WHO definitions have associated wheezing. The current strategies to diagnose and manage wheeze in the community need to be updated, as audible wheeze is present in only less than one third of wheezy children, and can not be relied upon ...
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Mouse models of T helper type 2 (Th2) cell–biased pulmonary inflammation have elucidated mechanisms of sensitization, cell traffic, and induced airway hyperresponsiveness (AHR). Nonetheless, most mice lack intrinsic AHR, a central property of human asthma, and disparities persist regarding the contributions of eosinophils and mast cells and the sensitivity to induced AHR in the commonly used mo...
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متن کاملA 68-year-old man with intractable dyspnea and wheezing 45 years after a pneumonectomy.
A 68-year-old man with a 20-year history of wheezing presented with a recent increase in dyspnea, productive cough, and inability to clear secretions. He denied fevers, rigors, chest pain, palpitations, lightheadedness, syncope, headaches, nasal symptoms, or gastroesophageal reflux. During the last 15 years, he received treatment with albuterol and ipratropium inhalers in addition to daily nebu...
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 201 شماره
صفحات -
تاریخ انتشار 2005